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Oral third generation cephalosporin, like cefixime has been found effective in treating multi-drug resistant typhoid fever in children and now clinically well practiced in bangladesh. Esbls have the ability to hydrolyse antibiotics containing an oxyimino group, namely cefotaxime, ceftazidime, ceftriaxone, cefpodoxime and aztreonam, but they are usually inactivated by inhibitors.